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M9550007.TXT
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1995-03-04
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Document 0007
DOCN M9550007
TI Anti-human immunodeficiency virus type 1 activities of U-90152 and
U-75875 in human brain cell cultures.
DT 9505
AU Peterson PK; Gekker G; Hu S; Chao CC; Department of Medicine, Hennepin
County Medical Center,; Minneapolis, MN 55415.
SO Antimicrob Agents Chemother. 1994 Oct;38(10):2465-8. Unique Identifier :
AIDSLINE MED/95142597
AB Antiviral activities of the reverse transcriptase inhibitors U-90152 and
3'-azido-2',3'-dideoxythymidine and the protease inhibitor U-75875 were
compared in two culture models of human immunodeficiency virus type 1
brain infection. In a model involving acutely infected microglial cells,
U-90152 was the most active, whereas in a model using chronically
infected promonocytes, U-75875 was the most active.
DE Antiviral Agents/*PHARMACOLOGY Brain/*VIROLOGY Cells, Cultured Human
HIV Protease Inhibitors/*PHARMACOLOGY HIV-1/*DRUG EFFECTS
Indoles/*PHARMACOLOGY Oligopeptides/*PHARMACOLOGY
Piperazines/*PHARMACOLOGY Reverse Transcriptase/*ANTAGONISTS & INHIB
Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Tumor Necrosis
Factor/BIOSYNTHESIS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).